Popping Molly is an American slang term which means to take ecstacy. “Molly” is slang for very high quality ecstacy, while “to pop” something is a colloquial way to say “to eat” or “to drink” something.
The term Pop Molly has recently become much more popular since American rapper Jay-Z’s release of the song “Tom Ford”. In this song Jay-Z raps “I don’t pop molly, I rock Tom Ford”. Tom Ford is a famous American fashion designer. This lyric compares the effects of ecstacy to the effects of wearing clothing designed by Tom Ford.
Likewise another rapper, Trinidad James, raps the lyrics “Popped a Molly I’m Sweatin” in his recent release “All Gold Everything”.